White, whose career in entertainment spanned more than eight decades, came to be known as Hollywood's grandmother.
Her quick wit, even in her later years, was beloved by all.
She gained national prominence as Sue Ann Nivens on "The Mary Tyler Moore Show" in the 1970s.
White is perhaps best known for her role as Rose on "The Golden Girls," the 1980s sitcom that broke boundaries by providing a starring vehicle for later-aged actresses.
Even into her 90s, White worked regularly. She had a starring role on the sitcom "Hot in Cleveland" until the show ended its run in 2015.
White also lit up movie screens with memorable roles in the horror spoof “Lake Placid” and the comedy “The Proposal,” alongside actors Ryan Reynolds and Sandra Bullock.
She really gained notoriety when she starred in a Snickers commercial that ran during the Super Bowl in 2010.
Afterward, she co-hosted "Saturday Night Live," for which she won her seventh Emmy award.
White's death comes just days before her 100th birthday, which would have occurred on January 17.
Condolences from her famous friends began rolling in after news broke of her passing.
"Our national treasure, Betty White, has passed just before her 100th birthday," "Star Trek" star George Takei tweeted. "Our Sue Ann Nivens, our beloved Rose Nylund, has joined the heavens to delight the stars with her inimitable style, humor, and charm. A great loss to us all. We shall miss her dearly."
"Tonight we will raise MANY glasses to the WONDERFUL legacy of Betty White!!!" Bravo's Andy Cohen said on Twitter.
"Betty White: It is very hard to absorb you are not here anymore.." "Happy Days" actor Henry Winkler said. "But the memories of your deLIGHT are ..Thank you for your humor, your warmth, and your activism .. Rest now and say Hi to Bill."
She was also an ardent advocate for animal welfare.